Alignment of alleles: Atlantic cod (Gadus morhua) IGHV3S27

When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Germline genomic sequences are needed to confirm if the nucleotide substitutions result from somatic mutations or correspond to allelic polymorphisms.

                                  1   2   3   4   5   6   7   8   9  10  11  12  13  14  15  16  17  18  19  20
                                 C   E   Q   L   T   Q   P   E   F       L   T   I   R   P   G   Q   P   L   T
  X76507  ,IGHV3S27*01, 101-11  TGT GAA CAG CTT ACT CAG CCG GAG TTT ... CTT ACT ATC CGA CCT GGT CAA CCT CTG ACC
                                                                 S               V  
  AJ279393,IGHV3S27*02, 42      --- --- --- --- --- --- --C --- -C- ... --G --- G-- --- --- --- --- --- --- ---

                                                        ___________________CDR1-IMGT____________________
                                 21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40
                                 I   R   C   Q   V   S   Y   S   V   S   S   Y   Y                       T   A
  X76507  ,IGHV3S27*01, 101-11  ATC CGC TGT CAG GTT TCT TAT TCT GTT AGT AGC TAC TAC ... ... ... ... ... ACA GCT
                                                                             H  
  AJ279393,IGHV3S27*02, 42      --- --- --- --- --C --- --- --- --- --- --- C-- --- ... ... ... ... ... --- ---

                                                                                            _______________CDR2-
                                 41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60 
                                 W   I   R   Q   P   E   G   H   A   L   E   W   I   G   M   I   K   T   G   D
  X76507  ,IGHV3S27*01, 101-11  TGG ATC AGA CAA CCT GAG GGA CAT GCA CTG GAA TGG ATT GGC ATG ATA AAG ACT GGG GAC
                                                                                         W       V  
  AJ279393,IGHV3S27*02, 42      --- --- --- --- --- --A --- --C --- --- --- --- --- --A TG- --T GTT --C --- ---

                                IMGT________________
                                 61  62  63  64  65  66  67  68  69  70  71  72  73  74  75  76  77  78  79  80
                                 K                   H   Q   K   D   S   L   S       S   K   F   S   L   A   V
  X76507  ,IGHV3S27*01, 101-11  AAA ... ... ... ... CAC CAG AAA GAC TCT CTT AGT ... AGT AAA TTC AGT CTT GCC GTT
                                                     R   V  
  AJ279393,IGHV3S27*02, 42      --- ... ... ... ... AGA GT- --- --T --C --- --- ... --- --- --- --- --- --- ---


                                 81  82  83  84  85  86  87  88  89  90  91  92  93  94  95  96  97  98  99 100
                                 D   G   S   S   K   T   V   T   L   Q   G   Q   N   M   Q   P   G   D   S   A
  X76507  ,IGHV3S27*01, 101-11  GAC GGC TCC AGT AAA ACA GTA ACT TTG CAA GGG CAA AAC ATG CAG CCT GGA GAC TCA GCT
                                                 N                                   L  
  AJ279393,IGHV3S27*02, 42      --- --- --- --- --C --- --- --- --- --- --- --G --- C-- --- --- --- --- --- ---

                                                _CDR3-IMGT__
                                101 102 103 104 105 106 
                                 V   Y   Y   C   D   R
  X76507  ,IGHV3S27*01, 101-11  GTG TAT TAC TGT GAT AGA     #c
                                                 A
  AJ279393,IGHV3S27*02, 42      --- --- --- --- -CC ---     #c
#c: rearranged cDNA

This alignment of allele is automatically generated by Mehdi Yousfi alignment of allele tool.

Created: 21/01/2002
Author: Nathalie Bosc